Enterococci are leading opportunistic pathogens in hospital settings and cause a variety of disease states including endocarditis, bacteremia, meningitis, wound infections, and urinary tract infections. The ability to form biofilms in vivo is critical for many enterococcus infections. The Kline lab is working to understand how Enterococci interact with other bacteria in biofilm communities that cause disease. Using a combination of genetics, genomics, biochemistry, and imaging, the Kline lab is combining mechanistic studies of virulence factor assembly with in vivo biofilm infection models to assess the contribution of Enterococcal surface structures to niche modulation and disease progression. 

Kline Lab website: www.ntu.edu.sg/home/kkline

PUBLICATIONS