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Ms YONG Mei Hui Adeline
PhD Student

Supervisor: Asst. Prof. Kimberly Kline

Project Title:  The Functions of HtrA in Enterococcus faecalis

Enterococcus is a commensal organism of the gastrointestinal tract of mammals. It causes life-threatening infections in humans in the nosocomial environment.  Bacterial pathogens carry factors that contribute to virulence via direct or indirect interactions with the host. These factors are usually found to be focally localised on the cell surface and mislocalisation of these factors may results in membrane stress. There has been increase evidences that proteases are known to involve in various aspects of protein quality control, including cellular response to protein-folding stress and degradation of misfolded and mislocalised cell envelope proteins. The aim of Adeline’s project is to understand how pili in Enterococcus faecalis are efficiently assembled.