Publications
Synthesis of cephalosporin-3'-diazeniumdiolates - a new class of biofilm dispersing NO-donor prodrugs activated by ß-lactamase
Reference: Chemical Communications (2013) 49: 4791-4793

Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin-3'-diazeniumdiolates as biofilm-targeted NO-donor prodrugs. Each of the compounds is shown to selectively release NO following reaction with the bacteria-specific enzyme β-lactamase and to trigger dispersion of Pseudomonas aeruginosa biofilms in vitro.

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Yepuri N. R., Barraud N., Kardak B. G., Kjelleberg S., Rice S. A. and Kelso M. J.

Published By
Yepuri N.R., Barraud N., Kardak B.G., Kjelleberg S., Rice S. A., Kelso M.J.