Immobilization of antibacterial dihydropyrrol-2-ones on functional polymer supports to prevent bacterial infections in vivo
Reference: Antimicrobial Agents and Chemotherapy (2012) 56(2): 1138-1141

Antibiotic-resistant Staphylococcus aureus is of great concern, as it causes a wide range of life-threatening infections. The current study demonstrates that dihydropyrrolone (DHP)-coated polyacrylamide substrates are effective in reducing the number of culturable clinical isolates of S. aureus in vitro in a dose-dependent manner and are able to reduce the pathogenic potential of staphylococcal infection in a subcutaneous infection model. Covalently bound DHPs therefore show great potential for use as an antimicrobial strategy in device-related applications.

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Ho K. K. K., Cole N., Chen R., Willcox M. D. P., Rice S. A. and Kumar N. 

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Ho K.K.K., Cole N., Chen R., Willcox M.D.P., Rice S. A., Kumar N.