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Eradicating biofilm infections: An update on current and prospective approaches

by da Silva R.A.G., Irina AFONINA, Kline K. A.

Reference: Current Opinion in Microbiology (2021) 63: 117-125

Research Cluster(s): Biofilm Biology

Programme(s): Biofilm Detection and Control Public Health & Medicine

Engineered lysins with customized lytic activities against enterococci and staphylococci

by Binte Muhammad Jai H.S., Dam L.C., Tay L.S., Koh J.J.W., Loo H.L., Kline K. A. , Goh

Reference: Frontiers in Microbiology (2020) 11: 574739

Research Cluster(s): Biofilm Biology

Programme(s): Biofilm Detection and Control

Cellular chaining influences biofilm formation and structure in group A Streptococcus

by Matysik A. S., Alicia Qian Ler Tan, TAN Qian Ler, Alicia, Anuradha VAJJALA, Kline K. A.

Reference: Biofilm (2020) 2: 100013.

Research Cluster(s): Biofilm Biology

Programme(s): Biofilm Detection and Control

Multiplex CRISPRi system enables the study of stage-specific biofilm genetic requirements in Enterococcus faecalis

by Irina AFONINA, Ong J., Chua J., Lu T., Kline K. A.

Reference: mBio (2020) 11: e01101-20

Research Cluster(s): Biofilm Biology

Programme(s): Biofilm Detection and Control Public Health & Medicine

Omics and systems approaches to study the biology and applications of lactic acid bacteria

by Papadimitriou K., Kline K. A., Renault P., Kok J.

Reference: Frontiers in Microbiology (2020) 11: doi: 10.3389/fmicb.2020.01786

Research Cluster(s): Biofilm Biology

Programme(s): Public Health & Medicine

The novel E. coli cell division protein, YtfB, plays a role in eukaryotic cell adhesion

by Bottomley A. L., Peterson E., Iosifidis G., Yong M. H. A., Hartley-Tassell L. E., Ansari S., McKenzie C., Burke C., Duggin I. G., Kline K. A., Harry E. J.

Reference: Scientific Reports (2020) 10: 6745-6745

Research Cluster(s): Biofilm Biology

Programme(s): Host Microbiome (Holobiont) Interactions Public Health & Medicine

Enterococcus faecalis manganese exporter MntE alleviates manganese toxicity and is required for mouse gastrointestinal colonization

by Lam L. N., Wong J.J., Chong K. K. L., Kline K. A.

Reference: Infection and Immunity (2020) 86: e00058-00020

Research Cluster(s): Biofilm Biology

Programme(s): Host Microbiome (Holobiont) Interactions Public Health & Medicine

Combined efficacy of an antimicrobial cationic peptide polymer with conventional antibiotics to combat multidrug-resistant pathogens

by Thappeta K.R.V., Vikhe Y. S., Yong M. H. A., Chan-Park M. B., Kline K. A.

Reference: ACS Infectious Diseases (2020) 6: 1228–1237

Research Cluster(s): Biofilm Biology

Programme(s): Public Health & Medicine

Streptococcus pyogenes capsule promotes microcolony-independent biofilm formation

by Matysik A. S., Kline K. A.

Reference: Journal of Bacteriology (2019) 201: e00052-00019

Research Cluster(s): Biofilm Biology

Dr Jekyll and Mr Hide: How Enterococcus faecalis subverts the host immune response to cause infection

by Kao H., Kline K. A.

Reference: Journal of Molecular Biology (2019) 431: 2932-2945

Research Cluster(s): Biofilm Biology

Programme(s): Host Microbiome (Holobiont) Interactions

Biofilm-associated infection by enterococci

by Ch'ng J.H., Chong K. K. L., Lam L. N., Wong J.J., Kline K. A.

Reference: Nature Reviews Microbiology (2019) 17: 82-94

Research Cluster(s): Biofilm Biology

Programme(s): Host Microbiome (Holobiont) Interactions Biofilm Detection and Control

Streptolysin-induced endoplasmic reticulum stress promotes group A Streptococcal host-associated biofilm formation and necrotizing fasciitis

by Anuradha VAJJALA, Biswas D., Tay W. H., Hanski E., Kline K. A.

Reference: Cellular Microbiology (2018) 21: e12956

Research Cluster(s): Biofilm Biology

Programme(s): Host Microbiome (Holobiont) Interactions

Planktonic interference and biofilm alliance between aggregation substance and endocarditis- and biofilm-associated pili in Enterococcus faecalis

by Afonina I., Lim X. N., Tan R., Kline K. A.

Reference: Journal of Bacteriology (2018) 200: e00361-00318

Research Cluster(s): Biofilm Biology

Programme(s): Public Health & Medicine

A dual-function antibiotic-transporter conjugate exhibits superior activity in sterilizing MRSA biofilms and killing persister cells

by Antonoplis A., Zang X., Huttner M. A., Chong K. K. L., Lee Y. B., Co J. Y., Amieva M. R., Kline K. A. , Wender P. A., Cegelski L.

Reference: Journal of the American Chemical Society (2018) 140: 16140-16151

Research Cluster(s): Biofilm Biology

Programme(s): Biofilm Detection and Control

Extracellular electron transfer powers Enterococcus faecalis biofilm metabolism

by Keogh D., Lam L. N., Doyle L. E., Matysik A. S., Pavagadhi S., Umashankar S., Low P.M., Dale J.L., Song Y., Ng S.P., Boothroyd C.B., Dunny G.M., Swarup S., Williams R. B. H., Marsili E., Kline K. A.

Reference: mBio (2018) 9: e00626-00617.

Research Cluster(s): Biofilm Biology Environmental Engineering Meta-'omics & Microbiomes

Programme(s): Host Microbiome (Holobiont) Interactions

Anhydrous polymer-based coating with sustainable controlled release functionality for facile, efficacious impregnation, and delivery of antimicrobial peptides

by Lim K., Saravanan R., Chong K. K. L., Goh H. M. S., Chua R. R. Y., Tambyah P. A., Chang M. W., Kline K. A., Leong S. S. J.

Reference: Biotechnology and Bioengineering (2018) 115: 2000-2012

Research Cluster(s): Biofilm Biology

Programme(s): Biofilm Detection and Control

Membrane adaptation limitations in Enterococcus faecalis underlie sensitivity and the inability to develop significant resistance to conjugated oligoelectrolytes

by Gayatri CHILAMBI, Gao H. I., Yoon B.K., Park S., Kawakami L.M., Ravikumar V., Chan-Park M.B., Cho N.-J., Bazan G. C., Kline K. A., Rice S. A., Hinks J.

Reference: RSC Advances (2018) 8: 10284-10293

Research Cluster(s): Biofilm Biology Environmental Engineering

In vivo anti-biofilm and anti-bacterial non-leachable coating thermally polymerized on cylindrical catheter

by Zhou C., Wu Y., Thappeta K.R.V., Subramanian J. T. L., Pranantyo D., Kang E. T., Duan H., Kline K. A., Chan-Park M. B.

Reference: ACS Applied Materials & Interfaces (2017) 9: 36269-36280

Research Cluster(s): Biofilm Biology

Programme(s): Host Microbiome (Holobiont) Interactions Biofilm Detection and Control

Urinary catheter-associated microbiota change in accordance with treatment and infection status

by Bossa L., Kline K. A., McDougald D., Lee B.B., Rice S. A.

Reference: PLoS ONE (2107) 12: 1-20.

Research Cluster(s): Biofilm Biology

Programme(s): Host Microbiome (Holobiont) Interactions

Enterococcus faecalis promotes innate immune suppression and polymicrobial catheter-associated urinary tract infection

by Tien B. Y. Q., Goh H. M. S., Chong K. K. L., Tagore S. B., Holec S., Dress R., Ginhoux F., Ingersoll M. A., Williams R. B. H., Kline K. A.

Reference: bioRxiv (2017) doi.org/10.1101/133140

Research Cluster(s): Biofilm Biology

Programme(s): Integrative Analysis Unit

Extracellular Electron Transfer in Enterococcus faecalis Biofilm Metabolism

by Keogh D., Lam L. N., Doyle L. E., Matysik A. S., Pavagadhi S., Umashankar S., Dale J. L., Dunny G. M., Swarup S., Williams R. B. H., Marsili E., Kline K. A.

Reference: bioRxiv (2017) doi.org/10.1101/130146

Research Cluster(s): Biofilm Biology

Programme(s): Integrative Analysis Unit

Model systems for the study of Enterococcal colonization and infection

by Goh H. M. S., Yong M. H. A., Chong K. K. L., Kline K. A.

Reference: Virulence (2017) 8: 1525-1562.

Research Cluster(s): Biofilm Biology

Programme(s): Experimental Biofilms & Synthetic Ecology Host Microbiome (Holobiont) Interactions

Enterococcal metabolite cues facilitate interspecies niche modulation and polymicrobial infection

by Keogh D., Tay W. H., Ho Y. Y., Dale J. L., Chen S., Umashankar S., Williams R. B. H., Chen S. L., Dunny G. M., Kline K. A.

Reference: Cell Host & Microbe (2016) 20: 493-503.

Research Cluster(s): Biofilm Biology

Programme(s): Integrative Analysis Unit

Bladder catheterization increases susceptibility to infection that can be prevented by prophylactic antibiotic treatment

by Rousseau M., Goh H. M. S., Holec S., Albert M. L., Williams R. B. H., Ingersoll M. A., Kline K. A.

Reference: JCI Insight (2016) 1: e88178

Research Cluster(s): Biofilm Biology Meta-'omics & Microbiomes

Programme(s): Biofilm Detection and Control Integrative Analysis Unit

Focal targeting of the bacterial envelope by antimicrobial peptides

by Rashid R., Veleba M., Kline K. A.

Reference: Frontiers in Cell and Developmental Biology 4(55): doi.org/10.3389/fcell.2016.00055

Research Cluster(s): Biofilm Biology

Gram-positive uropathogens, polymicrobial urinary tract infection, and the emerging microbiota of the urinary tract

by Kline K. A., Lewis A.L.

Reference: Microbiology Spectrum (2016) 4(2): doi:10.1128/microbiolspec.UTI-0012-2012

Research Cluster(s): Biofilm Biology

Infection in an aging population

by Kline K. A., Bowdish D.M.E.

Reference: Current Opinion in Microbiology (2016) 29: 63-67

Research Cluster(s): Biofilm Biology

Impact of host age and parity on susceptibility to severe urinary tract infection in a murine model

by Kline K. A., Schwartz D.J., Gilbert N., Lewis A.L.

Reference: PloS ONE (2014) 9(5): e97798

Research Cluster(s): Biofilm Biology

Focal targeting by human beta defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis

by Kandaswamy K., Liew T.H., Wang C.Y., Huston-Warren E., Meyer-Hoffert U., Hultenby K., Schröder J.M., Caparon M.G., Staffan Normark, Henriques-Normark B., Hultgren S.J., Kline K. A.

Reference: Proceedings of the National Academy of Sciences USA (2013) 110(50): 20230-20235

Research Cluster(s): Biofilm Biology

Combination small molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice

by Guiton P.S., Cusumano C.K., Kline K. A., Dodson K.W., Han Z., Janetka J.W., Henderson J.P., Caparon M.G., Hultgren S.J.

Reference: Antimicrobial Agents and Chemotherapy (2012) 56(9): 4738-4745

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