News & Events
Biophysical studies of in vitro reconstituted chromatin
Speaker(s): Dr Nikolay Berezhnoy, Research Fellow, SCELSE
When: 12 April 2017 (3:00 - 4:00pm)
Where: SBS CR2 (Level 1)
Type: Seminars

Abstract

In vitro reconstituted chromatin is a model of chromatin found in the nuclei of eukaryotes. A variety of DNA templates and proteins prepared using recombinant technology allow the production of reasonable amounts of well-defined nucleosomes and nucleosome arrays. I will cover an introduction to chromatin, briefly describe production, and biophysical methods used to address some questions related to compaction and decompaction of chromatin. The regulation of compaction-decompaction of chromatin is a fundamental question of biology related to gene regulation in development, cancer and general well-being.