News & Events
The virulence and antibiotic potentials of zeamines
Speaker(s): Dr Zhou Jianuan (SCELSE)
When: 27 August 2015 (9:30)
Where: SBS Classroom 4 (Level 1)
Type: Seminars

Zeamines are new types of long chain aminated polyketide isolated from Dickeya zeae strain EC1, a pathogen causing soft rot disease on rice, resulting in great economic losses in rice yield. We have identified a gene cluster encoding the biosynthesis of zeamines, unique in all the D. zeae strains isolated from rice but other resources, suggesting association with host specificity. Zeamines can inhibit the germination of rice seeds and result in wilts of rice plants under a rarely low concentration; furthermore, inhibit the growth of many gram-positive and –negative bacteria, and fungi as well. We have explored its antifungal activity against Peronophythora litchi in vitro. Results showed that zeamines treatment significantly suppressed mycelial growth and sporangium germination of P.litchi under the concentration of 2μg/mL through ultrastructural modi?cations cell wall and endomembrane system. Zeamines also showed good killing effects on nematode worm Caenorhabditis elegans and Hela cells.