Synthesis of cephalosporin-3'-diazeniumdiolates - a new class of biofilm dispersing NO-donor prodrugs activated by ß-lactamase
Reference: Chemical Communications (2013) 49: 4791-4793

Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin-3'-diazeniumdiolates as biofilm-targeted NO-donor prodrugs. Each of the compounds is shown to selectively release NO following reaction with the bacteria-specific enzyme β-lactamase and to trigger dispersion of Pseudomonas aeruginosa biofilms in vitro.

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Yepuri N. R., Barraud N., Kardak B. G., Kjelleberg S., Rice S. A. and Kelso M. J.

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Yepuri N.R., Barraud N., Kardak B.G., Kjelleberg S., Rice S. A., Kelso M.J.