News & Events
Modulation of hemostatic mechanisms in severe infectious diseases
Speaker(s): Prof. Heiko Herwald, Lund University
When: 05 August 2015 (2pm)
Where: CR2 [SBS-01n-22]
Type: Seminars

Abstract:

Despite modern antibiotics, bacterial infections account for a considerable clinical burden that is often combined with high morbidity and mortality rates. Though the molecular mechanisms behind invasive and severe bacterial infections are far from being understood, it is generally believed that dysregulated immune reactions play an important role in these states of disease. In severe infectious diseases, the host response is because of the rapid progression almost entirely dependent on the innate immune system. Considering the amplitude of some innate defense mechanisms, their selectivity for pathogenic microorganisms is not always guaranteed and thus, there is a risk that some immune reactions may also have a deleterious impact on the host. For instance, hemostatic disorders, modulation of pro- and anti-inflammatory cascades, and impairment of vascular integrity can contribute to a great deal to the pathogenicity of the disease process. A better understanding of the molecular mechanisms behind the induction of such complications, will open new possibilities for the discovery of more advanced strategies to develop novel anti-microbial treatments and tools for diagnosis.