News & Events
High throughput genomic analysis to rewind the clock on the evolution of drug resistant tuberculosis
Speaker(s): Dr. Ashlee Earl, The Broad Institute of MIT & Harvard
When: 17 February 2016 (3pm)
Type: Seminars

Drug resistant tuberculosis (DR-TB) is an urgent and growing threat as multi-, extensively- and even totally-drug resistant (MDR, XDR and TDR) cases of TB are increasingly reported.  Incomplete knowledge of the mutations that give rise to drug resistance in the causative agent of TB, Mycobacterium tuberculosis, has hampered development of point-of-care molecular diagnostics that would enable effective TB patient management and decrease DR-TB emergence.  With our partners, we have sequenced and analyzed geographically and phenotypically diverse collections of M. tuberculosis to analyze the evolution of DR-TB and to create a more comprehensive catalog of DR-associated mutations.  I will discuss findings from this work, which include insights into the step-wise evolution of XDR-TB within an epidemic region and its relevance for global TB control.