News & Events
Infection in chronic wounds and endoscopic devices: a clinical focus
Speaker(s): Prof. Paolo Persichetti MD, Asst Prof. Giovanni Marangi MD, Dr Francesco Segreto MD, Dr Margherita Pizzicannella MD, Università Campus Bio-Medico di Roma, Italy
When: 29 March 2017 (3:00 - 4:00pm)
Where: SBS CR2 (Level 1)
Type: Seminars


A wound that has failed to re-epithelialise after three months is defined as chronic. Over four million patients in the United States are affected by chronic wounds, and around 50 billion US dollars are spent every year on their treatments. Such wounds can complicate with infection, sepsis or cancerisation, sometimes leading to amputation. Even with uncomplicated ulcers the patient’s quality of life is reduced by pain, need for frequent medications as well as by the resulting functional and social limitations. Surgical reconstruction is often unfeasible due to poor local tissues, comorbidities and local infection. As a consequence, surgical debridement followed by secondary healing stands as a mainstay. It would be paramount for these patients to speed up the re-epithelialisation process. However, the presence of biofilm results in chronic bacterial colonisation with poor response to antibiotic therapy. In this seminar, the presenter will review the current state of the art in the treatment of chronic wounds, ranging from conventional medication to regenerative medicine.

Infection transmission through flexible endoscopes after reprocessing 

Flexible endoscopes are likely to be a vehicle of microbial transmission. Since they cannot undergo a heat-sterilisation, the current approach to endoscopes reprocessing, involves a complex and expensive procedure of cleaning, High Level Disinfection (HLD), rinsing, drying, and storage. The formation of bacterial biofilms in endoscope channels, especially in duodenoscope due to the particular design of the elevator region, can withstand the disinfection. Even when endoscope reprocessing strongly follows current guidelines, unexpected breakdowns in infection control can occur leading to patient-to-patient transmission of potential multidrug-resistant organisms. The actual transmission during endoscopy may go underestimated because of inadequate surveillance, low frequency, or absence of clinical symptoms. In our presentation, we will discuss flexible endoscope contamination after reprocessing as a public health concern.