News & Events
Bypassing Barriers: Ultrasound-enhanced Drug Delivery to Cancer
Speaker(s): Asst Prof. James Kwan, School of Chemical and Biomedical Engineering, Nanyang Technological University.
When: 09 November 2016 (3:00 - 4:00pm)
Where: SBS CR2 (Level 1)
Type: Seminars

Abstract 

Modern chemotherapeutics are currently incapable of homogenous distribution throughout a tumour. Yet, complete treatment is crucial for therapeutic success. As a result, there has been a surge in ultrasound-responsive strategies that enhance the transport of therapeutics. Here, we present novel nanoscopic particles that trap bubbles within nano-crevices, and function as nucleation agents for inertial cavitation enhanced transport. We demonstrate that these nanodevices reproducibly generate inertial cavitation for extended periods of time, and facilitate enhanced drug penetration in both in vitro and in vivo cancer models. Additionally, we show that the inertial cavitation threshold and dynamics for these nano-devices can be reliably predicted over a range of frequencies using a modified Raleigh-Plesset equation for crevice-stabilised bubbles.
 
Speaker's Bio
 
For nearly a decade, Asst Prof. James Kwan has developed ultrasound technologies targeted towards enhancing the efficacy of therapies across multiple diseases. His most recent work was the invention and development of an ultrasound-responsive gas-stabilising solid nanoparticle. He was awarded the W.W. Spooner Junior Research Fellowship at the University of Oxford for his work in this field. Asst Prof. Kwan has published peer-reviewed journal articles in prestigious journals such as Journal of Controlled Release, Small, and Theranostics, and also co-authored book chapters, accruing nearly 500 citations in total. In addition, he has two patents, which have been licensed to separate spinout companies in the USA and UK. Asst Prof. Kwan seeks to continue pioneering stimulus-responsive strategies such as ultrasound and cavitation to address challenges in both biomedical and industrial applications.