News & Events
Molecular characterisation of a globally disseminated multidrug resistant Escherichia coli clone
Speaker(s): Prof. Mark Schembri, School of Chemistry and Molecular Biosciences, University of Queensland.
When: 22 June 2015 (10:00 am)
Where: SBS Classroom 2 (Level 1)
Type: Seminars

Abstract:

Many multidrug resistant (MDR) bacterial strains are now recognized as belonging to clones that originate in a specific locale, country or even globally. Escherichia coli sequence type 131 (ST131) is one such recently emerged and globally disseminated MDR pandemic clone responsible for community and hospital acquired urinary tract and bloodstream infections. E. coli ST131 was identified in 2008 as a major clone linked to the spread of the CTX-M-15 extended-spectrum β-lactamase (ESBL)-resistance. Since then, E. coli ST131 has also been strongly associated with fluoroquinolone resistance, as well as co-resistance to aminoglycosides and trimethoprim-sulfamethoxazole. In this seminar, I will discuss our recent work on the molecular characterisation of E. coli ST131, including: (i) the use of genome sequencing to demonstrate its rapid and recent global dispersal, (ii) the development of a high-throughput transposon mutagenesis system in combination with next generation sequencing to define specific virulence features of E. coli ST131, and (iii) the potential of anti-adhesion FimH inhibitors as an alternative treatment against MDR E. coli.