A/Prof CHNG Shu Sin
Biofilm Biology cluster, SCELSE
Department of Chemistry, NUS

A/Prof Chng’s laboratory in NUS focuses on understanding lipid trafficking processes in the context of outer membrane biogenesis in Gram-negative bacteria and mycobacteria. Specifically, his research group studies how lipids are transported between the inner and outer membranes in these organisms. In Gram-negative bacteria such as Escherichia coli, the group aims to elucidate mechanisms for phospholipid transport, and currently focuses on the OmpC-Mla and Tol-Pal complexes. In mycobacterial species including Mycobacterium smegmatis, the focus shifts towards understanding mycolic acid transport, particularly via the lipid flippase MmpL3. At SCELSE, Shu Sin's group also studies how PQS (Pseudomonas quinolone signal), a hydrophobic quorum sensing molecule, is transported across the cell envelope in Pseudomonas aeruginosa. Understanding lipid trafficking pathways in bacteria may allow the discovery of novel inhibitors that can influence outer membrane biology and overcome antimicrobial resistance.

Link to A/Prof Chng's website

SCELSE publications