Solid-phase synthesis of NH-1,2,3-triazoles using 4,4'-bismethoxybenzhydryl azide
Reference: Synlett (2014) 25(13): 1891-1895

Readily available 4,4′-bismethoxybenzhydryl azide was found to be a useful building block for the synthesis of NH-1,2,3-triazoles through copper(I)-catalyzed cycloaddition reactions with solid-supported terminal alkynes, followed by acid-mediated deprotection. Peptide-containing NH-1,2,3-triazoles were obtained in good yield and excellent purity (typically >95%).


Cohrt A. E., Le Quement S. T. and Nielsen T. E.

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Cohrt A.E., Le Quement S.T., Nielsen T.E.