A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema
Reference: Gut Microbes (2020) 12: e1801964-1801962

Evidence is accumulating that the establishment of the gut microbiome in early life influences the development of atopic eczema. In this longitudinal study, we used integrated multi-omics analyses to infer functional mechanisms by which the microbiome modulates atopic eczema risk. We measured the functionality of the gut microbiome and metabolome of 63 infants between ages 3 weeks and 12 months with well-defined eczema cases and controls in a sub-cohort from the Growing Up in Singapore Toward Healthy Outcomes (GUSTO) mother-offspring cohort. At 3 weeks, the microbiome and metabolome of allergen-sensitised atopic eczema infants were characterised by an enrichment of Escherichia coli and Klebsiella pneumoniae, associated with increased stool D-glucose concentration and increased gene expression of associated virulence factors. A delayed colonisation by beneficial Bacteroides fragilis and subsequent delayed accumulation of butyrate and propionate producers after 3 months was also observed. Here, we describe an aberrant developmental trajectory of the gut microbiome and stool metabolome in allergen sensitised atopic eczema infants.

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Ta L. D. H., Chan J. C. Y., Yap G. C., Purbojati R., Moses D.A., Koh Y. M. , Tay C. J. X., Huang C.-H., Kioh D. Y. Q., Woon J. Y., Tham E. H., Loo E. X. L., Shek L. P. C., Karnani N., Goh A., Van Bever H. P. S., Teoh O. H., Chan Y. H., Lay C., Knol J., Yap F., Tan K. H., Chong Y.-S., Godfrey K. M., Kjelleberg S., Schuster S.C., Chan E. C. Y., Lee B. W.