A/Prof Kevin Pethe

PI, Biofilms & Health cluster, SCELSE
Associate Professor, Infectious Disease/Assistant Dean, Research, Lee Kong Chian School of Medicine, NTU

Email: kevin.pethe@ntu.edu.sg

A/Prof Pethe’s research focuses on understanding bacterial metabolic and bioenergetics adaptation during host colonisation for the development of innovative strategies to control disease progression. This focus includes characterising metabolic synthetic lethal genetic interactions in bacteria, and his laboratory is using a chemical genomics approach to decipher how multiple metabolic perturbation can lead to the collapse of an entire biological system, knowledge which is critical to develop antibiotic drug combinations.

A related interest is to study the system-level perturbation induced by antibiotics using an interdisciplinary approach combining functional genomics, chemical biology, genetics and biochemistry. He is working on tuberculosis, leprosy, and several multi-drug resistant bacteria responsible for life-threatening nosocomial infections