SCELSE’s Biofilm Biology, Mechanisms & Ecology projects delve into the complex world of biofilms, which are structured microbial communities embedded in a self-produced extracellular polymeric matrix. The research focuses on understanding the genetic, chemical, and physical interactions involving microbial cells within biofilms as well as the structure and function of the matrix, all of which influence, biofilm’s formation, maintenance, and resistance. SCELSE employs cutting-edge technologies such as high-resolution imaging, omics-based analyses, and biophysical approaches to study biofilm structure and function. This interdisciplinary research is pivotal for identifying the factors that contribute to biofilm robustness. It offers means by which biofilms can be harnessed for desired outcomes, or potential targets are identified for controlling biofilm-related challenges, with applications in healthcare, industry, and environmental management.

• Mechanisms of biofilm formation and maintenance
• Role of extracellular polymeric substances (EPS) in biofilm structure
• Biofilm interactions in mixed-species communities
• Genetic and metabolic pathways in biofilms
• High-resolution imaging of biofilm architecture

SCELSE decodes the biofilm matrix to reveal how DNA, proteins, and polysaccharides give biofilms their strength and resilience. Using cutting-edge imaging at micro and nano scales, researchers uncover the hidden architecture of biofilms – critical insights that drive powerful new strategies to disrupt and control biofilms in medicine, industry, and beyond.