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Ms GAO Hanxing Iris
Research Assistant

Project title: Antimicrobial peptide resistance in Enterococcus faecalis.

As an opportunistic pathogen, Enterococcus faecalis causes more than 20 million cases of infections per year. Recently, there are increasing reports of multi-drug resistant E. faecalis, which makes it particularly important and urgent to evaluate the last-resort antibiotics in use and also to look for new solutions. Antimicrobial peptides, including daptomycin and polymyxin B, have been used as the last-line defense for many bacteria. Daptomycin and polymyxin B mainly act on the cell membrane. However, it remains unclear how E. faecalis gains resistance to these peptides. This research will help to reveal bacterial response to antimicrobial peptides and to introduce new treatment strategies.